Merck
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8.07491

Sigma-Aldrich

Polyethylene glycol 6000

for synthesis

Synonym(s):
Poly(ethylene glycol), Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 6000, PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
EC Index Number:
500-038-2

vapor pressure

<0.01 hPa ( 20 °C)

Quality Level

form

solid

autoignition temp.

420 °C

potency

28000 mg/kg LD50, oral (Rat)
>20000 mg/kg LD50, skin (Rabbit)

pH

5-7 (20 °C, 100 g/L in H2O)

mp

58-63 °C

transition temp

flash point 270 °C

density

1.2 g/cm3 at 20 °C

storage temp.

2-30°C

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible polymer that has a wide range of uses in PEGylation, surface conjugation, nanoparticle coating, and crosslinking for hydrogels, etc. PEGs are made by polymerizing ethylene oxide via a ring-opening reaction to produce a wide range of molecular weights and molecular weight distributions (polydispersity).

Application

Polyethylene glycol 6000 is a non-ionic surfactant that can be used as a structure-directing agent to prepare mesoporous γ-Al2O3. PEG 6000 induced the formation of the lamellate structure morphology of boehmite nanoparticles with improved textural properties such as high surface area, larger pore volume, and pore size. It is also used in drug formulations to enhance the dissolution rate of the poorly water-soluble drug molecule. PEG-6000 can also be used in the purification of nucleic acids via the selective precipitation method. This approach is economically cost-effective and faster than the commonly employed chromatographic purification method.

Analysis Note

Melting range (lower value): ≥ 59 °C
Melting range (upper value): ≤ 64 °C
Hydroxyl value: 16 - 23
Average molecular mass: 5000 - 7000
Identity (IR): passes test

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

281.5 °F - closed cup

Flash Point(C)

138.6 °C - closed cup

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