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Column performance test mixture of liquid chromatography

NIST® SRM® 870



certified reference material

Quality Level


pkg of 5 x 1.1 mL




pharmaceutical (small molecule)


multi-component solution

General description

This Standard Reference Material (SRM) is a mixture of five organic compounds in methanol and is intended for use in characterizing general aspects of liquid chromatographic (LC) column performance, including efficiency, void volume, methylene selectivity, retentiveness, and activity toward chelators and organic bases. Other possible uses include column classification to aid column selection during method development, as a control material for monitoring LC column performance over time, and in quality control for column manufacturing.

SRM 870 consists of a mixture of the following five organic compounds in methanol: uracil, toluene, ethyl benzene, quinizarin, and amitriptyline (added as amitriptyline hydrochloride; see Figure 1 for structures). A unit of SRM 870 consists of five ampoules each containing approximately 1.1 mL of the mixture. For more information, please refer to the SDS and COA.

SRM 870_cert SRM 870 _SDS


1.1 mL

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

Signal Word


Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids



Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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