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Merck

PHR1090

Dopamine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Dopamine hydrochloride

Synonym(s):

2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride

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1 G

€81.50

€81.50


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About This Item

Linear Formula:
(HO)2C6H3CH2CH2NH2·HCl
CAS Number:
Molecular Weight:
189.64
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-527-8
Beilstein/REAXYS Number:
3656720
MDL number:

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Product Name

Dopamine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

InChI key

CTENFNNZBMHDDG-UHFFFAOYSA-N

SMILES string

Cl[H].NCCc1ccc(O)c(O)c1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. D2690000
traceable to USP 1225204

API family

dopamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

248-250 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

Gene Information

human ... ADRB1(153)

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1 of 4

This Item
BP468436581225204
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

300

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

certified reference material, TraceCERT®

grade

pharmaceutical primary standard

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Dopamine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry,[1][2] colorimetry and chromatography.[3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dopamine is a neurotransmitter which is a naturally occurring catecholamine. Dopamine hydrochloride salt is indicated as a medicine for the treatment of acute congestive and renal failures.[1]

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7131 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Intropin (dopamine hydrochloride) intravenous admixture compatibility
Gardella LA, et al.
American Journal of Hospital Pharmacy, 32(6), 575-578 (1975)
Rapid Spectrophotometric Determination Of Dopamine Hydrochloride With Chloramine - T
Nagaraja P, et al.
Indian Journal of Pharmaceutical Sciences, 60(2), 99-99 (2016)
Spectrophotometric methods for the determination of certain catecholamine derivatives in pharmaceutical preparations
Nagaraja P, et al.
Talanta, 46(1), 39-44 (1998)
Darae Kang et al.
Poultry science, 100(3), 100964-100964 (2021-03-04)
The effects of early heat conditioning on the acute heat stress response in broilers were investigated via the growth performance, dopamine, serotonin, and corticosterone and the expression of heat shock proteins (HSP) and heat shock factors. One-day-old chicks (n =
A Jon Stoessl et al.
Lancet (London, England), 384(9942), 532-544 (2014-06-24)
Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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