Solution stability has not been determined for this product, however commercial and pharmaceutical preparations are cited as being stable at room temperature for up to 18 months, protected from light. Folic acid is also a component of most of the classical DMEM media formulations, for example D5546. These products are also assigned a shelf life of 18 months, but are stored at 2 - 8 deg. C. Storing at -20 deg. C may or may not extend the shelf life. There is a possibility that the freeze/thaw process may result in precipitation and may be detrimental.
F8758
Folic acid
BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%
Synonym(s):
Pterylmonoglutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
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5 G
€49.30
25 G
€173.00
About This Item
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
34058014
UNSPSC Code:
12352205
EC Number:
200-419-0
MDL number:
Beilstein/REAXYS Number:
100781
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Product Name
Folic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable
InChI key
OVBPIULPVIDEAO-LBPRGKRZSA-N
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
SMILES string
NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
biological source
synthetic
product line
BioReagent
assay
≥97%
form
powder
mol wt
Mw 441.40 g/mol
color
dark yellow
solubility
1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange
storage temp.
room temp
Quality Level
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This Item | F0300000 | 1286005 | Y0001979 |
|---|---|---|---|
| technique(s) cell culture | insect: suitable, cell culture | plant: suitable, cell culture | mammalian: suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) - | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable |
| assay ≥97% | assay - | assay - | assay - |
| biological source synthetic | biological source synthetic | biological source - | biological source synthetic |
| form powder | form solid | form - | form solid |
| solubility 1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange | solubility - | solubility - | solubility - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
Application
Biochem/physiol Actions
A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.
Storage Class
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
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Folic acid handling by the human gut: implications for food fortification and supplementation
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Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study
Li Z, et al.
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Articles
Explore folic acid importance in serum-free eukaryotic cell cultures, including CHO cells, and its role in media supplementation.
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Product Information Sheet
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Is it better to store folic acid (Product No. F8758) solution at RT or -20'C? Also, how long is it stable as a solution for at recommended temperature?
1 answer-
Helpful?
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What is the stability of folic acid (Product No. F8758) once in solution?
1 answer-
This product is photolabile and is inactivated by UV light. Alkaline solutions are reasonably stable in the dark, but heating will destroy both alkaline and acidic solutions.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solubility of folic acid (Product No. F8758)?
1 answer-
Product No. F8758 is soluble in 1 M NaOH (50 mg/mL). The free acid is only slightly soluble in water (0.01 mg/mL at 0 °C), and is insoluble in aqueous solutions below pH 5. It is soluble in sodium bicarbonate or sodium hydroxide solutions.
Helpful?
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Is Product No. F8758, Folic Acid, tested for endotoxins?
1 answer-
No, Product No. F8758 has not been tested for endotoxins. This product has, however, been tested for use in mammalian cell culture and insect cell culture.
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