M7439

Methyl-β-cyclodextrin

• Synonym(s): Methyl-beta-cyclodextrin
• CAS Number: 128446-36-6
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 200
• mp: 180-182 °C (lit.)
• InChI: 1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
• InChI key: QGKBSGBYSPTPKJ-UHFFFAOYSA-N

Description

General description

Methyl-β-cyclodextrin is a small cyclic heptasaccharide.

Application

Methyl-β-cyclodextrin has been used as a cholesterol chelator:

• to study its effects on mice cardiomyocytes
• to study its effects on human corneal stromal fibroblasts
• to study its effects on the junctophilin-2 (JPH2) pool

Biochem/physiol Actions

Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): 368.6 °F
• Flash Point(C): 187 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves