The product is tested for solubility in water at 50mg/ml. Stock solutions may be stored in aliquots at -20°C for up to 4 months.
N5751
Nω-Nitro-L-arginine methyl ester hydrochloride
≥97% (TLC), powder, nitric oxide production inhibitor
Synonym(s):
L-NAME HCl, L-NAME hydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
250 MG
€29.20
1 G
€48.30
5 G
€158.00
10 G
€273.00
25 G
€560.00
About This Item
Empirical Formula (Hill Notation):
C7H15N5O4 · HCl
CAS Number:
Molecular Weight:
269.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
257-116-1
MDL number:
Beilstein/REAXYS Number:
3744166
Skip To
Product Name
Nω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
InChI key
QBNXAGZYLSRPJK-JEDNCBNOSA-N
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
SMILES string
Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
biological source
synthetic
assay
≥97% (TLC)
form
powder
color
white to off-white
mp
132 °C
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
Looking for similar products? Visit Product Comparison Guide
Related Categories
1 of 4
This Item | N5501 | I8021 | P7340 |
|---|---|---|---|
| assay ≥97% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) | assay ≥98% (TLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 50 mg/mL | solubility 1 M HCl: 50 mg/mL, clear, colorless to faintly yellow | solubility water: 50 mg/mL, clear, colorless | solubility water: 50 mg/mL, clear, colorless |
| color white to off-white | color - | color - | color - |
Application
Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
- to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons[1]
- to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin[2]
- to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells[3]
- to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat[4]
Biochem/physiol Actions
Arginine analog that inhibits NO production.
General description
Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
Amanda E Boe et al.
Circulation, 128(21), 2318-2324 (2013-10-05)
Long-term inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-))
Biological effect of far-infrared therapy on increasing skin microcirculation in rats
Yu SY, et al.
Photodermatology, Photoimmunology & Photomedicine, 22(2), 78-86 (2006)
Anne-Clémence Vion et al.
Circulation research, 112(10), 1323-1333 (2013-03-29)
Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. EMP levels were quantified
P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Related Content
Product Information Sheet
-
Following reconstitution, what is the recommended storage temperature and how long it will remain stable?
1 answer-
Helpful?
-
-
Is Product N5751, L-NAME hydrochloride, an inhibitor of Nitric Oxide Synthase (NOS)?
1 answer-
L-NAME was described as a reversible, non-specific inhibitor of nitric oxide synthase by Khavandgar. S. et al., Pharmacol. Biochem. Behav., 74, 795 (2003).
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
How do I sterilize a prepared solution of Product N5751, L-NAME hydrochloride?
1 answer-
Solutions of this product may be sterile-filtered.
Helpful?
-
-
What is the solution stability of Product N5751, L-NAME hydrochloride?
1 answer-
Although we do not perform solution stability studies, one literature reference recommends keeping solutions on ice during the course of one day.
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service