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SML0488

Sigma-Aldrich

Dobesilate Calcium

≥98% (HPLC)

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Synonym(s):
2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate
Empirical Formula (Hill Notation):
C6H5O5S · 0.5Ca
CAS Number:
20123-80-2
Molecular Weight:
209.20
MDL number:
MFCD00867249
PubChem Substance ID:
329825438
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

room temp

SMILES string

[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O

InChI

1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2

InChI key

QGNBTYAQAPLTMX-UHFFFAOYSA-L

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This Item
SML023421230445568
Dobesilate Calcium ≥98% (HPLC)

Sigma-Aldrich

SML0488

Dobesilate Calcium

Mitiglinide calcium ≥98% (HPLC)

Sigma-Aldrich

SML0234

Mitiglinide calcium

Calcium propionate ≥97.0% (dry substance, NT)

Sigma-Aldrich

21230

Calcium propionate

Calcium methoxide 97%

Sigma-Aldrich

445568

Calcium methoxide

form

powder

form

powder

form

-

form

solid

color

white to beige

color

white to beige

color

-

color

-

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

solubility

water: soluble 1 g/10 mL, clear, colorless

solubility

-

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

General description

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Application

Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.

Biochem/physiol Actions

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI?1.
Zhang X
Experimental and Therapeutic Medicine, 5(1), 295-299 (2013)
Xiuzhi Guo et al.
Medicine, 94(23), e905-e905 (2015-06-11)
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical
Jaimi A Gray et al.
BMC evolutionary biology, 19(1), 7-7 (2019-01-10)
Morphological diversity among closely related animals can be the result of differing growth patterns. The Australian radiation of agamid lizards (Amphibolurinae) exhibits great ecological and morphological diversity, which they have achieved on a continent-wide scale, in a relatively short period
Xiuzhi Guo et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 1-5 (2018-04-14)
We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according
Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays.
Guo X, et al.
PLoS ONE, 13(2), e0192440-e0192440 (2018)
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