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Dexterity Kits are an easy, all-in-one method to perform high sensitivity proximity labeling for any protein as long as there is a known antibody or small molecule specific for their protein of interest (POI). These protein labeling kits allow you to perform precise micromapping within 4 nm of your POI. Dexterity Kits provide:
The fragment DELs from our partner DyNAbind provides an entire screening library in a single tube, making your drug discovery process faster, more effective, and less expensive. We’ve lowered the barriers to DyNAbind DEL technology to provide:
This DNA-encoded library from our partner DyNAbind contains a library of 10 million small molecule compounds each tagged with a DNA barcode. This DEL provides:
With our selection of reactive groups, scaffolds, linkers and tags, you can design probes to include functionalities compatible for:
Choose from probes with high-specificity for one target or subset of a protein to provide insight into biological processes, protein activity and localization, and cell signaling networks.
Probes containing an alkyne, azide or tetrazine handle are paired with bioorthogonally compatible fluorescent or biotinylated tags
Detect cell proliferation especially for in vivo experiments with the EdU nucleoside:
Access a library of molecules from the Dale Boger lab with broad spectrum inhibition of the serine hydrolase family. Tune the compounds to a desired reactivity and selectivity through functional group attachment at an amine site and develop inhibitors to specific subclasses of serine hydrolase enzymes.
Quorum sensing is a chemical communication mechanism used by many common bacteria. New quorum sensing modulators developed by the Helen Blackwell laboratory are some of the most potent inhibitors and activators reported for Gram-negative species.
We offer crosslinkers that vary in length, solubility and functional group reactivity.
We also provide crosslinkers designed for click chemistry reactivity.
As a unique class of functional groups, KATS:
We offer Baran Diversinate crosslinkers with a metal sulfinate on one end to attach directly to otherwise inert C-H bonds and an azide on the other end for attaching to alkynes. We offer various alkyne and strained alkyne crosslinkers for attachment to the azide crosslinker.