From single-use to multi-use, our tangential flow filtration (TFF) products are ideal for pharma and biopharma manufacturing.
Single-pass TFF with our Pellicon® capsules and cassettes streamlines processing by concentrating process streams without the recirculation of traditional TFF. This is a simple way to increase capacity, concentration, and product recovery while improving footprint. This versatile application also enables continuous and intensified processing, in which in-line volume reduction is coupled to other process steps.
Pellicon® Capsules with Ultracel® membrane are designed for streamlined ultrafiltration and diafiltration of biopharmaceuticals, offering ease of use and process flexibility. This innovative capsule is a true single-use TFF device with a unique plug-and-play, holderless design that comes ready to process in minutes.
Pellicon® 3 cassettes deliver high protein yield and consistent performance while offering broad chemical compatibility. They are available with Ultracel® and Biomax® membranes for different processing needs, including mAbs, plasma, insulin, peptides, and vaccines. To overcome high viscosity challenges, our Pellicon® 3 cassettes with D screen are optimized to achieve higher protein concentrations.
Pellicon® 2 cassettes are ideal for the ultrafiltration and diafiltration of biologics including concentration, desalting, and buffer exchange of polysaccharides, virus suspensions, and protein solutions. Our Ultracel® and Biomax® membranes offer efficient ultrafiltration while Durapore® membrane is best suited for microfiltration.
Pellicon® XL 50 cassettes couple our ultrafiltration and microfiltration membranes with linear scalability for process development or small-volume processing.
Prostak™ microfiltration modules provide robust construction, reliable performance, and steam-in-place capability, making them suitable for clarification, cell harvest, and multi-use perfusion. The low hold-up volume and open channel design allow high product recovery and gentle flow path for processing shear-sensitive materials.
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Performance Guide: Pellicon® Capsules with Ultracel® Membrane Performance Guide
Application Note: Pellicon® Capsules for Single-use Tangential Flow Filtration
Application Note: Pellicon® Capsules for Ultrafiltration/Diafiltration in the Antibody Drug Conjugate Manufacturing Process
Article: ADC Review: Trial of High Efficiency TFF Capsule Prototype for ADC Purification
Article: European Biopharmaceutical Review: Novel TFF Capsule Evaluation
Performance Guide: Pellicon® 3 Cassettes with Ultracel® Membrane Performance Guide
Performance Guide: Pellicon® 3 Cassettes with Biomax® Membrane Performance Guide
Application Note: Performance Evaluation and Cleanability Study using Pellicon® 3 Cassettes with 30 kD Biomax® and Ultracel® Ultrafiltration Membranes
Application Note: Pellicon® 3 Cassettes with High Viscosity Feed Screen
Application Note: Process Optimization and Scalability Evaluation of Pellicon® Capsules for Single-pass Tangential Flow Filtration of mAb-Based Biomolecules
Article: Adding Versatility with Single-Pass TFF
White Paper: Streamlining Bioprocessing Using Pellicon® Cassettes for Single-pass Operation
Data Sheet: Pellicon® 3 Cassettes with Ultracel® Membrane
Data Sheet: Pellicon® 3 Cassettes with Biomax® Membrane
Data Sheet: Pellicon® 2 Filters and Holders
Data Sheet: Pellicon® XL 50 Cassette and Labscale® TFF System
Data Sheet: Prostak™ Microfiltration Modules
An overview of TFF solutions for achieving high viscosity of monoclonal antibodies and plasma IgG, and strategies for reliable cycle-to-cycle cleaning.
An overview of single-use TFF capsules for single-pass tangential flow filtration (SPTFF) of mAbs and other therapeutic proteins.
A new approach which combines SPTFF with Eshmuno® Q chromatography resin for intensified mAb polishing.