Skip to Content
Merck

Sterile Filters

The image shows a person in a white coat and purple gloves holding a small vial with a blue liquid.

Sterile filtration is an important step in the drug production process and is routinely implemented for bacterial removal throughout bioprocessing to achieve bioburden control.

For sterile filtration of aqueous liquids, we offer filters containing Durapore® polyvinylidene fluoride (PVDF) membranes and Millipore Express® filters containing polyethersulfone (PES) membranes. For sterile filtration of non-aqueous liquids, polytetrafluoroethylene (PTFE) membranes are available.



Selecting the right filter

Choosing the right sterilizing filter and device format for the process step or application is key to developing an efficient, cost-effective process. You can be confident our filter portfolio encompasses the standard-setting products your work deserves.
Filter selection is dependent on the feed characteristics and particulate levels, the level of contamination risk, and the specific process step. For critical aseptic processing operations, sterilizing-grade filters are the preferred solution. For non-critical or “low risk” operations such as buffer filtration and column protection, bioburden reduction filters may be used. 

  • All filters are fully scalable from small-scale tools to pilot and production-scale manufacturing
  • Most are offered as single-use capsules or cartridge filters
  • For plugging streams, high-area formats double the membrane area, without increasing filter footprint
  • Filters are offered in autoclavable, gamma-compatible or pre-sterilized formats with different connection options

Regulatory Compliance

Complementing our product portfolio, the Emprove® Program consolidates comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.


Related Product Resources

Page 1 of 2




Related Webinars

Family of Millipore Express cartridges, opticap capsules and optiscale
Find Your Filter – Which Aseptic Filter is Best for Your Process?

This webinar summarizes filter design, criteria for filter selection, and how new filter choices can maximize your productivity.

A digital illustration of a laptop displaying a simplistic human figure next to a pink rectangle, all set against a yellow background.
Selection, Sizing, and Operation of Bioprocess Filtration Trains for Optimal Performance

In this webinar, you will learn how filters for microfiltration of biological fluids work, the effect of operating conditions on filtration performance, and how to design an optimal series filtration (prefilter and final filter) process.

A digital illustration of a laptop displaying a simplistic human figure next to a pink rectangle, all set against a yellow background.
Potential Impact of Draft Annex 1 on Sterilizing Filtration

This webinar compares the current version of Annex 1 with the proposed changes and highlight areas of specific interest to companies who either manufacture in or export to EMA countries, PICS member countries, and WHO compliant countries.

A digital illustration of a laptop displaying a simplistic human figure next to a pink rectangle, all set against a yellow background.
Does Your SVP Process Assure Sterile Drug Product?

In this webinar you will learn about the importance of sterilizing grade filters for removal of microorganisms from small volume parenterals, why this last unit operation in the process is a critical step, and how to make it effective for successful manufacturing.

Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?