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Sulfoxide-Containing Mass Spectrometry (MS)-Cleavable Cross-Linkers
Learn about homobifunctional sulfoxide-containing MS-cleavable cross-linkers that enables the capture of protein-protein interactions (PPIs) in native cellular environments, and the identification of cross-linked peptides permits the determination of both identity and connectivity of PPIs.
Multiplex Quantification of Infliximab and Adalimumab in Human Serum by LC-MS/MS Using Full-Length Stable Isotope Labeled Internal Standards
Infliximab and Adalimumab monoclonal antibodies (mAbs) are used widely to treat rheumatoid arthritis, psoriatic arthritis, and many autoimmune diseases by binding to tumor necrosis factor-alpha (TNFα) to reduce the inflammatory response.
Residual Solvents from Food Packaging
Residual Solvents from Food Packaging
Mass Spectrometry
What is Mass Spectrometry or MS? What is it used for and how does it work? Read this detailed article with diagrams and example graphs to understand how to use mass spec in your research.
Analytical Reference Standards: Synthesis and Characterization
As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance.
SPME in the Analysis of Illicit Drugs
SPME is used in the analysis of amphetamine compounds by doing pre-extraction derivatization, and is also used in general determinations of other drugs of abuse.
Bioanalysis with SPME
Biocompatible SPME devices employ C18 bonded porous silica sorbent particles, in a binder which resists fouling by biological matrix components
Comparison of QuEChERS Products for the Extraction of Planar Pesticides from Spinach
Supel™ QuE Verde combines a novel carbon with zirconia coated silica (Z-Sep+) to provide an optimum balance between planar pesticide recovery and color removal.
LC/MS/MS Method for Determination of Glyphosate, AMPA, and Glufosinate in Cereals
Glyphosate and related compounds are measured in oatmeal and infant cereal using ion-exchange polymer-based particles for HPLC and SPE. Low level detection was obtained.
Characterization of Stable Isotope Caffeine as Reference Material for Isotope Dilution Mass Spectrometry
This technique is based on the direct proportionality of mass fraction ratio and signal intensity ratio of the natural isotope and the C-13 labeled caffeine.
Analysis of Pesticides in Baby Food by Solid Phase Microextraction (SPME) Using a New Overcoated Fiber
A direct immersion SPME method using a new overcoated SPME fiber was developed for the extraction of pesticides from pureed prune baby food.
Isolation and LC-MS Characterization of Illicit Bath Salts in Urine
The combination of ion-exchange SPE with the HILIC HPLC separation provides a novel approach for the testing of problematic bath salt compounds.
Hopane Reference Standards for use as Petrochemical Biomarkers in Oil Field Remediation and Spill Analysis
We provide high-quality, relevant hopane reference standards to be used as biomarkers for petrochemical oil field remediation and spill analysis.
Class-Selective Enantiomeric Separation of beta-Blockers and beta-Agonists using CHIROBIOTIC T Stationary Phase
Understanding the role of chirality in pharmacology became extremely important following the tragedy of thalidomide use in the 1960s. At that time the effect of chirality was poorly understood, and whilst it was discovered that the sedative effect resided in
Evaluation of LCMSMS Deuterium Scrambling in Clinically Significant Small Molecules
LC-MS/MS is a powerful tool that brings numerous benefits to the clinical sample analysis arena. However, due to the complexity of the instrumentation there are some unique challenges that also accompany these benefits. Even following sample extraction and cleanup, matrix
How to Maximize Sensitivity in LC-MS
Various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown on this page. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.
Ion-Suppression & Phospholipid Contamination
We are presenting an article focusing on ion-suppression and phospholipid contamination and some of their major causes and difficulties.
Supel-Select HLB SPE for Pharmaceutical Analysis
Select HLB SPE is a hydrophilic polymer phase for analyte extraction from aqueous matrices. Here it’s used for statins in plasma and 48 pharmaceutical analytes in drinking water.
Improved GC/MS Derivatization Techniques for Analysis of New Designer Drugs: Methylone, Ethylone, Butylone, Mephedrone, and Methedrone
As new “bath salt” drugs such as methylone, ethylone, mephedrone, butylone and other methcathinone analogs increase in popularity, toxicologists require native and labeled certified reference materials to accurately identify and quantify the new compounds in patient samples.
Resolving by Mass
Resolving by Mass
Online Solid Phase Extraction and LC/MS Analysis of Thyroid Hormones in Human Serum
An online SPE-LC/MS method has been developed for the rapid detection of thyroid hormones in human serum with minimal hands on effort and time-consuming steps.
Extraction of Nitroimidazoles from Milk and Eggs using Molecularly Imprinted Polymers
In this report, SupelMIP SPE – Nitroimidazoles was evaluated for the extraction of nitroimidazoles and metabolites from milk and egg.
HybridSPE®-Phospholipid Technology
Innovative solid phase extraction (SPE) technology from Supelco, utilizes phospholipid retention mechanism based on highly selective interaction between proprietary zirconia ions (bonded to the stationary phase) and the phosphate moiety consistent with phospholipids and proteins.
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
Quantification of bitter acids in hops by thin layer chromatography
HPTLC separation followed by UV detection of the bitter acid content in various hop samples.
Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep
Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep
An LC/MS Peptide Standard for Rapid System Suitability Assessment and Retention Time Translation Across LC/MS Platforms
Standards are critical in liquid chromatography/mass spectrometry (LC/MS) based proteomics to ensure optimal and consistent system performance before, during, and after sample analysis.
Ion Pairing for Analysis of Phosphonate Compounds
Phosphonates are a class of compounds commonly used for therapeutic applications of antiviral drugs. These compounds can be difficult to analyze due to their highly polar nature and lack of UV active chromophores.
Method Validation for Determination of Chloramphenicol in Urine Using Molecularly Imprinted Polymer (MIP) SPE
The method for determination of low concentrations of chloramphenicol in bovine and porcine urine was developed. Sample cleanup was performed by Molecular Imprinted Polymer (MIP) columns. Confirmatory analyses were conducted using GC/MS-NCI after derivatisation (silylation). The described method was fully
Validation of RNAi Knockdown Using Multiple Reaction Monitoring and Protein-AQUA
The field of proteomics is continually looking for new ways to investigate protein dynamics within complex biological samples. Recently, many researchers have begun to use RNA interference (RNAi) as a method of manipulating protein levels within their samples, but the
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