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Merck

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

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ELISA

Product Number
Description
Species
RAB0530
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
EZHS42
High Sensitivity Human Amyloid β42 ELISA, ,
Species
human
EZHS40
High Sensitivity Human Amyloid β40 ELISA, ,
Species
human
EZBRAIN42
Human Amyloid β42 Brain ELISA, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
C1386
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
MAB348
Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11, clone 22C11, Chemicon®, from mouse,
Species Reactivity
canine, fish, human, monkey, mouse, pig, rat
Application
immunofluorescence
immunohistochemistry
western blot
AB5078P
Anti-Beta-Amyloid 1-42 Antibody, Chemicon®, from rabbit,
Species Reactivity
chicken, human, mouse
Application
ELISA
immunohistochemistry
western blot
MAB5206
Anti-Amyloid Antibody, β 1-16, clone DE2, culture supernatant, clone DE2, Chemicon®,
Species Reactivity
bovine, human, monkey
Application
ELISA
immunohistochemistry
western blot
MABN11
Anti-Amyloid β40 Antibody, clone G2-10, clone G2-10, from mouse,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
MAB5208
Anti-Amyloid Antibody, β 1-16, clone AB10, clone AB10, Chemicon®, from mouse,
Species Reactivity
bovine, human, monkey
Application
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot

Proteins

Product Number
Description
Species
AG968
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human, ,
Species
human
AG970
β Amyloid 1-42, aβ, ultra pure, NaOH, recombinant human, ,
Species
human
03-0146-00
SMC® Amyloid Beta 42 High Sensitivity Immunoassay Kit, ,
Species
AG964
β Amyloid 1-40, aβ, ultra pure, NaOH, recombinant human, ,
Species
human
AG916
β Amyloid 1-42, aβ, scrambled, TFA, recombinant E. coli, ,
Species
human