ARRB2
arrestin, beta 2
Synonyms:
ARB2, ARR2, BARR2
Species:
Human ARRB2 (409), Mouse Arrb2 (216869), Rat Arrb2 (25388), domestic guinea pig Arrb2 (100716149), Domestic Rabbit ARRB2 (100341204), sheep ARRB2 (101112493), cow ARRB2 (281638), Horse ARRB2 (100072892), domestic cat ARRB2 (101093558), dog ARRB2 (607262)
UniProtKB ID:
Gene ID:
- Human(409) Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
- Mouse(216869) arrestin, beta 2
- Rat(25388) arrestin, beta 2
- domestic guinea pig(100716149) arrestin, beta 2
- Domestic Rabbit(100341204) arrestin, beta 2
- sheep(101112493) arrestin, beta 2
- cow(281638) arrestin, beta 2
- Horse(100072892) arrestin, beta 2
- domestic cat(101093558) arrestin, beta 2
- dog(607262) arrestin, beta 2
- naked mole-rat(101709908) arrestin, beta 2
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