DPH1
diphthamide biosynthesis 1
Synonyms:
DPH2L, DPH2L1, OVCA1
Species:
Human DPH1 (1801), Mouse Dph1 (116905), Rat Dph1 (287523), sheep DPH1 (101104511), chicken DPH1 (417564), cow DPH1 (534099), dog DPH1 (480653), domestic cat DPH1 (101083810), naked mole-rat Dph1 (101700222), Zebrafish dph1 (550559) ...More
UniProtKB ID:
Gene ID:
- Human(1801) Summary: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]
- Mouse(116905) DPH1 homolog (S. cerevisiae)
- Rat(287523) DPH1 homolog (S. cerevisiae)
- sheep(101104511) DPH1 homolog (S. cerevisiae)
- chicken(417564) DPH1 homolog (S. cerevisiae)
- cow(534099) DPH1 homolog (S. cerevisiae)
- dog(480653) DPH1 homolog (S. cerevisiae)
- domestic cat(101083810) DPH1 homolog (S. cerevisiae)
- naked mole-rat(101700222) diphthamide biosynthesis 1
- Zebrafish(550559) DPH1 homolog (S. cerevisiae)
- domestic guinea pig(100715978) diphthamide biosynthesis 1
- Horse(100060117) DPH1 homolog (S. cerevisiae)
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