FPGS
folylpolyglutamate synthase
Synonyms:
Species:
Human FPGS (2356), Mouse Fpgs (14287), Rat Fpgs (687266), sheep FPGS (101101964), Horse FPGS (100070426), Domestic Rabbit FPGS (100357704), dog FPGS (609176), Zebrafish fpgs (406746), cow FPGS (505809), domestic cat FPGS (101092966) ...More
UniProtKB ID:
Gene ID:
- Human(2356) Summary: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
- Mouse(14287) folylpolyglutamyl synthetase
- Rat(687266) folylpolyglutamate synthase
- sheep(101101964) folylpolyglutamate synthase
- Horse(100070426) folylpolyglutamate synthase
- Domestic Rabbit(100357704) folylpolyglutamate synthase
- dog(609176) folylpolyglutamate synthase
- Zebrafish(406746) folylpolyglutamate synthase
- cow(505809) folylpolyglutamate synthase
- domestic cat(101092966) folylpolyglutamate synthase
- domestic guinea pig(100725303) folylpolyglutamate synthase
- naked mole-rat(101720293) folylpolyglutamate synthase
- chicken(417227) folylpolyglutamate synthase
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