PC
pyruvate carboxylase
Synonyms:
PCB
Species:
Human PC (5091), Mouse pc (18517), Rat Pc (25104), Zebrafish pc (58068), fruit fly Pc (40358), chicken PC (374263), dog PC (483704), domestic cat PC (101089547), Horse PC (100052853), cow PC (100531427) ...More
UniProtKB ID:
Gene ID:
- Human(5091) Summary: This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(18517) phocomelic
- Rat(25104) pyruvate carboxylase
- Zebrafish(58068) pyruvate carboxylase
- fruit fly(40358) Polycomb
- chicken(374263) pyruvate carboxylase
- dog(483704) pyruvate carboxylase
- domestic cat(101089547) pyruvate carboxylase
- Horse(100052853) pyruvate carboxylase
- cow(100531427) Milk protein content
- cow(338471) pyruvate carboxylase
- cow(102030942) Milk protein content
- cow(102031061) Milk protein content
- cow(102030982) Milk protein content
- cow(102030897) Milk protein content
- cow(102030716) Milk protein content
- cow(102030715) Milk protein content
- cow(102030714) Milk protein content
- Goat(100861129) pyruvate carboxylase
- sheep(101107484) pyruvate carboxylase
- domestic guinea pig(100719498) pyruvate carboxylase
- naked mole-rat(101711800) pyruvate carboxylase
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