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Merck

PCBP2

poly(rC) binding protein 2

Synonyms:
HNRNPE2, HNRPE2, hnRNP-E2
Species:
Human PCBP2 (5094), Mouse Pcbp2 (18521), Rat Pcbp2 (363005), naked mole-rat Pcbp2 (101702918), Zebrafish pcbp2 (321844), dog PCBP2 (477596), domestic cat PCBP2 (101086733), Horse PCBP2 (100062163), cow PCBP2 (540653), sheep PCBP2 (101103142)
UniProtKB ID:
Q15366, A8K7X6, F8VYL7, I6L8F9, Q32Q82, Q59HD4, Q68Y55, Q6IPF4
Gene ID:
  • Human(5094) Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(18521) poly(rC) binding protein 2
  • Rat(363005) poly(rC) binding protein 2
  • naked mole-rat(101702918) poly(rC) binding protein 2
  • Zebrafish(321844) poly(rC) binding protein 2
  • dog(477596) poly(rC) binding protein 2
  • domestic cat(101086733) poly(rC) binding protein 2
  • Horse(100062163) poly(rC) binding protein 2
  • cow(540653) poly(rC) binding protein 2
  • sheep(101103142) poly(rC) binding protein 2
  • domestic guinea pig(100731593) poly(rC) binding protein 2

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