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Merck

PRKG1

protein kinase, cGMP-dependent, type I

Synonyms:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Species:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), chicken PRKG1 (423682), Horse PRKG1 (100071872), naked mole-rat Prkg1 (101708361), sheep PRKG1 (100294616), sheep PRKG1 (101117124), domestic cat PRKG1 (101097420), domestic guinea pig Prkg1 (100734084) ...More
UniProtKB ID:
Q13976, E2PU10, P14619, Q5JSJ6, Q6P5T7
Gene ID:
  • Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
  • Mouse(19091) protein kinase, cGMP-dependent, type I
  • Rat(54286) protein kinase, cGMP-dependent, type 1
  • chicken(423682) protein kinase, cGMP-dependent, type I
  • Horse(100071872) protein kinase, cGMP-dependent, type I
  • naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
  • sheep(100294616) protein kinase, cGMP-dependent, type I
  • sheep(101117124) protein kinase, cGMP-dependent, type I
  • domestic cat(101097420) protein kinase, cGMP-dependent, type I
  • domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
  • dog(609616) protein kinase, cGMP-dependent, type I
  • Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
  • cow(282004) protein kinase, cGMP-dependent, type I

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Antibodies

Product Number
Description
Species Reactivity
Application
09-101
Anti-cGMP (cyclic GMP) Antibody, serum, Upstate®,
Species Reactivity
all
Application
ELISA
immunohistochemistry
radioimmunoassay

Proteins

Product Number
Description
Species
14-688-M
PKG1α Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.,
Species
human