STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms:
APRF, HIES
Species:
Human STAT3 (6774), Mouse Stat3 (20848), Rat Stat3 (25125), naked mole-rat Stat3 (101721899), domestic guinea pig Stat3 (100717084), chicken STAT3 (420027), Zebrafish stat3 (30767), sheep STAT3 (100294659), domestic cat STAT3 (101095698), cow STAT3 (508541) ...More
UniProtKB ID:
Gene ID:
- Human(6774) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(20848) signal transducer and activator of transcription 3
- Rat(25125) signal transducer and activator of transcription 3 (acute-phase response factor)
- naked mole-rat(101721899) signal transducer and activator of transcription 3 (acute-phase response factor)
- domestic guinea pig(100717084) signal transducer and activator of transcription 3 (acute-phase response factor)
- chicken(420027) signal transducer and activator of transcription 3 (acute-phase response factor)
- Zebrafish(30767) signal transduction and activation of transcription 3
- sheep(100294659) signal transducer and activator of transcription 3 (acute-phase response factor)
- domestic cat(101095698) signal transducer and activator of transcription 3 (acute-phase response factor)
- cow(508541) signal transducer and activator of transcription 3 (acute-phase response factor)
- Horse(100052852) signal transducer and activator of transcription 3 (acute-phase response factor)
- Domestic Rabbit(100348778) signal transducer and activator of transcription 3 (acute-phase response factor)
- dog(490967) signal transducer and activator of transcription 3 (acute-phase response factor)
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ELISA
Product Number
Description
Species
Phosphotyrosine STAT3 / Signal Transducer and Activator of Transcription 3 ELISA Kit, ,
Species
human
Cell-Based ELISA for detecting phospho-STAT3 (pTyr705) in cultured cell lines, 96 assays,
Species
mouse, rat, human
Phospho-Stat3 (pTyr705) ELISA Kit, for detection of phospho-stat3 (pTyr705) in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human
Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit, for detection of phospho-stat3 (pTyr705) and pan-stat3 in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-STAT3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-STAT3 (Tyr705) Antibody, clone 9E12, clone 9E12, Upstate®, from mouse,
Species Reactivity
canine, human, mouse
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Stat3 Antibody, from rabbit,
Species Reactivity
bovine, human, mouse, pig, porcine, primate, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-STAT3 Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
ChIP
electrophoretic mobility shift assay
immunocytochemistry
immunoprecipitation (IP)
western blot
electrophoretic mobility shift assay
immunocytochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-Stat3 (Tyr705) Antibody, clone 6C3, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey, mouse, rat
Application
immunohistochemistry
inhibition assay
western blot
inhibition assay
western blot