TMPRSS2
transmembrane protease, serine 2
Synonyms:
PP9284, PRSS10
Species:
Human TMPRSS2 (7113), Mouse Tmprss2 (50528), Rat Tmprss2 (156435), cow TMPRSS2 (511037), sheep TMPRSS2 (101120216), Zebrafish tmprss2 (494080), chicken TMPRSS2 (418528), domestic cat TMPRSS2 (101096004), naked mole-rat Tmprss2 (101715175), domestic guinea pig Tmprss2 (100732077)
UniProtKB ID:
Gene ID:
- Human(7113) Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
- Mouse(50528) transmembrane protease, serine 2
- Rat(156435) transmembrane protease, serine 2
- cow(511037) transmembrane protease, serine 2
- sheep(101120216) transmembrane protease, serine 2
- Zebrafish(494080) transmembrane protease, serine 2
- chicken(418528) transmembrane protease, serine 2
- domestic cat(101096004) transmembrane protease, serine 2
- naked mole-rat(101715175) transmembrane protease, serine 2
- domestic guinea pig(100732077) transmembrane protease, serine 2
- dog(487770) transmembrane protease, serine 2
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