TYK2
tyrosine kinase 2
Synonyms:
JTK1
Species:
Human TYK2 (7297), Mouse Tyk2 (54721), Rat Tyk2 (100361294), domestic cat TYK2 (101090171), dog TYK2 (476714), chicken TYK2 (430113), Zebrafish tyk2 (100536675), cow TYK2 (512484), domestic guinea pig Tyk2 (100715734), sheep TYK2 (101117248)
UniProtKB ID:
Gene ID:
- Human(7297) Summary: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
- Mouse(54721) tyrosine kinase 2
- Rat(100361294) tyrosine kinase 2
- domestic cat(101090171) tyrosine kinase 2
- dog(476714) tyrosine kinase 2
- chicken(430113) tyrosine kinase 2
- Zebrafish(100536675) tyrosine kinase 2
- cow(512484) tyrosine kinase 2
- domestic guinea pig(100715734) tyrosine kinase 2
- sheep(101117248) tyrosine kinase 2
- naked mole-rat(101715782) tyrosine kinase 2
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