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78246

Supelco

Curcumin

matrix substance for MALDI-MS, ≥99.5% (HPLC)

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Synonym(s):
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
Linear Formula:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS Number:
Molecular Weight:
368.38
Colour Index Number:
75300
Beilstein:
2306965
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

matrix substance for MALDI-MS

Quality Level

vapor density

13 (vs air)

Assay

≥99.5% (HPLC)

form

powder

technique(s)

MALDI-MS: suitable

mp

183-188 °C

cation traces

Na: ≤50 mg/kg

storage temp.

2-8°C

SMILES string

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

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1 of 4

This Item
PHR2209C7727C1386
Curcumin matrix substance for MALDI-MS, ≥99.5% (HPLC)

78246

Curcumin

Curcumin Pharmaceutical Secondary Standard; Certified Reference Material

PHR2209

Curcumin

Curcumin ≥94% (curcuminoid content), ≥80% (Curcumin)

C7727

Curcumin

Curcumin from Curcuma longa (Turmeric), powder

C1386

Curcumin

assay

≥99.5% (HPLC)

assay

-

assay

≥80% (Curcumin), ≥94% (curcuminoid content)

assay

-

technique(s)

MALDI-MS: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

−20°C

grade

matrix substance for MALDI-MS

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Hirsutenone ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00096

Hirsutenone

Oregonin ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00088

Oregonin

Demethoxycurcumin analytical standard

Supelco

90593

Demethoxycurcumin

USP

USP

1151866

Curcuminoids

Demethoxycurcumin phyproof® Reference Substance

PHL89628

Demethoxycurcumin

Tetrahydrocurcumin ≥96% (HPLC)

Sigma-Aldrich

SMB00370

Tetrahydrocurcumin

Marie-Hélène Teiten et al.
Molecular nutrition & food research, 57(9), 1619-1629 (2013-06-12)
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as
Issac Abraham Sybiya Vasantha Packiavathy et al.
Food chemistry, 148, 453-460 (2013-11-23)
Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such
Michal Heger et al.
Pharmacological reviews, 66(1), 222-307 (2013-12-26)
This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the
Wing-Hin Lee et al.
Expert opinion on drug delivery, 11(8), 1183-1201 (2014-05-27)
Natural compounds are emerging as effective agents for the treatment of malignant diseases. Curcumin (diferuloylmethane), the active constituent of turmeric extract, has gained significant interest as a plant-based compound with anti-cancer properties. Curcumin is physiologically very well tolerated, with negligible
Anggakusuma et al.
Gut, 63(7), 1137-1149 (2013-08-02)
Hepatitis C virus (HCV) infection causes severe liver disease and affects more than 160 million individuals worldwide. People undergoing liver organ transplantation face universal re-infection of the graft. Therefore, affordable antiviral strategies targeting the early stages of infection are urgently

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