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  • STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

The EMBO journal (2017-04-06)
Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie-Pierre Chenard, Catherine Tomasetto, Guillaume Drin, Fabien Alpy
PMID28377464
ABSTRACT

StAR-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that creates endoplasmic reticulum (ER)-endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular distribution of this lipid was ill-defined. Here, by using