114715

Phenylhydrazine hydrochloride

≥99%

• Synonym(s): Phenylhydrazinium chloride
• Linear Formula: C₆H₅NHNH₂ · HCl
• CAS Number: 59-88-1
• Molecular Weight: 144.60
• Beilstein: 3594958
• EC Number: 200-444-7
• MDL number: MFCD00012924
• PubChem Substance ID: 24847191
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥99%
• form: solid
• mp: 250-254 °C (dec.) (lit.)
• solubility: H₂O: soluble 50 mg/mL
• SMILES string: Cl[H].NNc1ccccc1
• InChI: 1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H
• InChI key: JOVOSQBPPZZESK-UHFFFAOYSA-N

Description

Application

Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice.

Biochem/physiol Actions

Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals.

Preparation Note

50 gm of Phenylhydrazine hydrochloride dissolves in 1 mL of water to yield a clear, very faint yellow solution.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331 - H315 - H317 - H319 - H341 - H350 - H372 - H400
• Precautionary Statements: P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1
• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves