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245917

Sigma-Aldrich

Pentafluoropropionic acid

97%

Synonym(s):
Perfluoropropionic acid
Linear Formula:
CF3CF2COOH
CAS Number:
Molecular Weight:
164.03
Beilstein:
1773387
EC Number:
MDL number:
PubChem Substance ID:

vapor density

~5.6 (vs air)

Quality Level

vapor pressure

~40 mmHg ( 20 °C)

assay

97%

refractive index

n20/D 1.284 (lit.)

bp

96-97 °C (lit.)

density

1.561 g/mL at 25 °C (lit.)

SMILES string

OC(=O)C(F)(F)C(F)(F)F

InChI

1S/C3HF5O2/c4-2(5,1(9)10)3(6,7)8/h(H,9,10)

InChI key

LRMSQVBRUNSOJL-UHFFFAOYSA-N

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General description

The kinetics of the reaction of pentafluoropropionic acid with fluorine atoms was studied.

Application

Pentafluoropropionic acid (Perfluoropropionic acid) was used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods.
Pentafluoropropionic acid can be used to prepare 2-pentafluoropropylquinazolin-4(3H)-ones, perfluoroalkyl thioethers and perfluoroalkyl-containing 3-azabicyclo[3.1.0]hexanes.

Packaging

10, 50 g in glass bottle

pictograms

CorrosionSkull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo [3.1. 0] hexanes
Pedroni, Julia and Cramer, Nicolai
Journal of the American Chemical Society, 139(36), 12398-12401 (2017)
Synthesis of perfluoroalkyl thioethers from aromatic thiocyanates by iron-catalysed decarboxylative perfluoroalkylation
Exner, Benjamin and Bayarmagnai, Bilguun and Matheis, Christian and Goossen, Lukas J
Journal of Fluorine Chemistry, 198, 89-93 (2017)
E S Vasiliev et al.
The journal of physical chemistry. A, 118(23), 4013-4018 (2014-05-14)
The kinetics of the reaction between fluorine atoms and pentafluoropropionic acid has been studied experimentally at T = 262-343 K. The overall reaction rate constant decreases with temperature: k1(T) = 6.1 × 10(-13) exp(+1166 K)/T) cm(3) molecule(-1) s(-1). The potential...
One-Pot Synthesis of Trifluoromethylated Quinazolin-4 (3 H)-ones with Trifluoroacetic Acid as CF3 Source
Almeida, Sofia and Marti, Roger and Vanoli, Ennio and Abele, Stefan and Tortoioli, Simone
The Journal of Organic Chemistry, 83(9), 5104-5113 (2018)
B Li et al.
Journal of pharmaceutical and biomedical analysis, 55(1), 78-84 (2011-02-15)
Liquid chromatography combined with pulsed electrochemical detection (LC-PED) is the method of choice in the European Pharmacopoeia for the determination of gentamicin and its related substances. A recently approved improved LC-PED method, with a reversed-phase C(18) column and a mobile...

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