401633

1-Pyrenemethylamine hydrochloride

95%

• Synonym(s): PMA
• Empirical Formula (Hill Notation): C₁₇H₁₃N · HCl
• CAS Number: 93324-65-3
• Molecular Weight: 267.75
• MDL number: MFCD00192425
• PubChem Substance ID: 24865033
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 95%
• form: powder
• mp: 258 °C (dec.) (lit.)
• SMILES string: Cl[H].NCc1ccc2ccc3cccc4ccc1c2c34
• InChI: 1S/C17H13N.ClH/c18-10-14-7-6-13-5-4-11-2-1-3-12-8-9-15(14)17(13)16(11)12;/h1-9H,10,18H2;1H
• InChI key: RGNMXKKNDSHTFD-UHFFFAOYSA-N

Description

General description

1-Pyrenemethylamine hydrochloride is an organic building block.

Application

1-Pyrenemethylamine (PyNH₂) has also been used for the synthesis of:

• Pyrenyl hyaluronan (Py-HA), a pyrenyl-based polymer that can be used for the development of pH-triggered drug carriers.
• An electrochemical electrode of reduced graphene oxide bound with pyrene functionalized folic acid derivative.

It can also be used for the synthesis of 4,6-dichloro-2-pyrenemethylamine-1,3,5-triazine, a precursor to synthesize a star shaped polymer 4,6-bis(9H-carbazol-2-yloxy)-2-(pyrenemethylamine)-1,3,5 triazine (TPC).

1-Pyrenemethylamine hydrochloride (PyNH₂) has been used for the loading of human telomerase reverse transcriptase (hTERT) small interfering RNA (siRNA) to the functionalized graphene oxide (GO) for the tumor targeting delivery of siRNA.

1-Pyrenemethylamine hydrochloride has been used in the preparation of 1-pyrenemethylamine. It may be used for the noncovalent functionalization of SWNTs with cationic moieties which binds strongly to the negatively charged phosphate backbone of the DNA. It may be used in the preparation of the following Schiff-base ligand:

• pyren-1-ylmethyl-[2-(6-{2-[(pyren-1-ylmethylimino)-methyl]-phenoxymethyl}-pyridin-2-ylmethoxy)-benzylidene]-amine
• 2(pyren-1-ylmethyl-{2-[6-(2-{[(pyren-1-ylmethyl)-amino]-methyl}- phenoxymethyl)-pyridin-2-ylmethoxy])-benzyl}-amine

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves