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901577

Sigma-Aldrich

t-Boc-N-amido-PEG2-CH2CO2H

≥95%

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Empirical Formula (Hill Notation):
C11H21NO6
CAS Number:
Molecular Weight:
263.29
MDL number:

Assay

≥95%

form

liquid

reaction suitability

reagent type: linker

density

1.15 g/cm3 (lit.)

functional group

Boc
amine
carboxylic acid

storage temp.

−20°C

SMILES string

OC(COCCOCCNC(OC(C)(C)C)=O)=O

InChI

1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)

InChI key

OMBVJVWVXRNDSL-UHFFFAOYSA-N

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This Item
901575901572M3884
Bromo-PEG2-acid ≥95%

Sigma-Aldrich

901572

Bromo-PEG2-acid

form

liquid

form

liquid

form

liquid

form

-

reaction suitability

reagent type: linker

reaction suitability

reagent type: linker

reaction suitability

reagent type: linker

reaction suitability

reagent type: linker

density

1.15 g/cm3 (lit.)

density

-

density

-

density

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

functional group

Boc

functional group

Boc, amine, carboxylic acid

functional group

bromo, carboxylic acid

functional group

NHS ester

Application

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.
t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 3


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