This product can be stored at room temperature, tightly sealed, before and after opening.
D126608
2,6-Diisopropylphenol
97%
Synonym(s):
2,6-Bis(1-methylethyl)phenol, 2,6-Bis(isopropyl)phenol, Propofol
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5 G
PLN 146.00
100 G
PLN 276.00
About This Item
Linear Formula:
[(CH3)2CH]2C6H3OH
CAS Number:
Molecular Weight:
178.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-206-6
MDL number:
Assay:
97%
Form:
liquid
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InChI key
OLBCVFGFOZPWHH-UHFFFAOYSA-N
InChI
1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
SMILES string
CC(C)c1cccc(C(C)C)c1O
vapor pressure
5.6 mmHg ( 100 °C)
assay
97%
form
liquid
refractive index
n20/D 1.514 (lit.)
bp
256 °C/764 mmHg (lit.)
mp
18 °C (lit.)
density
0.962 g/mL at 25 °C (lit.)
Quality Level
Gene Information
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay 97% | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 300 | Quality Level 300 | Quality Level - |
| form liquid | form liquid | form - | form liquid |
| mp 18 °C (lit.) | mp - | mp 18 °C (lit.) | mp 18 °C (lit.) |
| bp 256 °C/764 mmHg (lit.) | bp - | bp 256 °C/764 mmHg (lit.) | bp 256 °C/764 mmHg (lit.) |
| refractive index n20/D 1.514 (lit.) | refractive index - | refractive index n20/D 1.514 (lit.) | refractive index n20/D 1.514 (lit.) |
General description
2,6-Diisopropylphenol, a strongly hydrophobic substituted phenol, is a new intravenous anaesthetic.[1] The antioxidant properties of 2,6-diisopropylphenol (Propofol) have been examined. It plays the role of an antioxidant by reacting with free radicals to form a phenoxyl radical, a property associated with all phenol-based free radical scavengers.[2] 2,6-diisopropylphenol is an effective intravenous hypnotic agent, widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit.[3] It is useful for the induction and maintenance of general anaesthesia.[1]
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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C Frenkel et al.
European journal of pharmacology, 208(1), 75-79 (1991-09-12)
Single sodium channels from human brain cortex tissue were incorporated into voltage-clamped planar lipid bilayers in the presence of batrachotoxin and studied with various doses of the new anaesthetic compound propofol (2,6-diisopropylphenol). Propofol was found to depress two major sodium
Paul E Marik
Current pharmaceutical design, 10(29), 3639-3649 (2004-12-08)
Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution.
Configurational rearrangements in cis-M (AA)2X2, cis-M (AA)2XY, and cis-M(AB)2X2 complexes.
Bickley DG and Serpone N.
Inorganic Chemistry, 18(8), 2200-2204 (1979)
P G Murphy et al.
British journal of anaesthesia, 68(6), 613-618 (1992-06-01)
We have examined in vitro the antioxidant properties of 2,6-diisopropylphenol. In studies using electron spin resonance spectroscopy we have demonstrated that 2,6-diisopropylphenol acts as an antioxidant by reacting with free radicals to form a phenoxyl radical--a property common to all
Annette P N Kutter et al.
Anesthesia and analgesia, 121(1), 99-107 (2015-03-06)
In critically ill patients with significant pulmonary hypertension (PH), close perioperative cardiovascular monitoring is mandatory, considering the increased morbidity and mortality in this patient group. Although the pulmonary artery catheter is still the standard for the diagnosis of PH, its
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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