QBD10243

Fmoc-N-amido-dPEG^®₂-acid

>95% (HPLC)

• Synonym(s): Fmoc-N-amido-PEG₂-COOH, Fmoc-N-amido-PEG₂-acid, Fmoc-PEG-acid, Fmoc-PEG₂-acid
• Empirical Formula (Hill Notation): C₂₂H₂₅NO₆
• Molecular Weight: 399.44
• MDL number: MFCD08064306

Properties

• Assay: >95% (HPLC)
• form: solid or viscous liquid
• reaction suitability: reaction type: Pegylations
• polymer architecture: shape: linear; functionality: homobifunctional
• shipped in: ambient
• storage temp.: −20°C

Description

Features and Benefits

Fmoc-N-amido-dPEG₂-acid is a monodisperse PEG product that is useful for peptide synthesis. The ten-atom dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEG_n-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable