Merck
  • QBD10903
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QBD10903

Sigma-Aldrich

Fmoc-N-amido-dPEG®36-acid

>95% (HPLC)

All Photos(1)
Synonym(s):
Fmoc-N-amido-PEG36-acid, Fmoc-NH-PEG36-acid, Fmoc-PEG-acid, Fmoc-PEG1500-acid, Fmoc-PEG36-acid
Empirical Formula (Hill Notation):
C90H161NO40
Molecular Weight:
1897.22
MDL number:
MFCD21363317

Assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

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assay

>95% (HPLC)

assay

>95% (HPLC)

assay

>95% (HPLC)

assay

>95% (HPLC)

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Biotinylations, reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Features and Benefits

Fmoc-N-amido-dPEG36-acid is a monodisperse PEG product that is useful for peptide synthesis. The 112-atom dPEG spacer allows the introduction of a long, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. Fmoc-N-amido-dPEG36-acid is the monodisperse PEG equivalent of polymeric PEG1500. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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