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1.07185

Sigma-Aldrich

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

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Synonym(s):
Pepsin
CAS Number:
Molecular Weight:
35000
MDL number:
EC Index Number:
232-629-3

pH

4.0-5.0 (20 °C, 10 g/L in H2O)

solubility

10 g/L

bulk density

380‑420 kg/m3

storage temp.

2-30°C

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This Item
1.0719277161P7012
Sigma-Aldrich

Sigma-Aldrich

1.07185

Pepsin

Sigma-Aldrich

Sigma-Aldrich

1.07192

Pepsin

solubility

10 g/L

solubility

10 g/L

solubility

-

solubility

deionized water: soluble 10 mg/mL, 10 mM HCl: soluble 4 mg/mL (Cold)

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

−20°C

bulk density

380‑420 kg/m3

bulk density

380‑420 kg/m3

bulk density

-

bulk density

-

Application

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Biochem/physiol Actions

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Analysis Note

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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