Anti-Phosphatidylserine may be used to detect translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer cell membrane leaflet; it provides an alternative to Annexin V for quantitation of apoptosis.
Phosphatidylserine, or PS, is a naturally occurring, phospholipid nutrient. PS is essential to the functioning of all the cells of the body, but is most concentrated in the brain. Its relative abundance in this organ reflects its proven involvement in an assortment of nerve cell functions, including nerve transmitter release and synaptic activity. Clinical studies have suggested that PS can support brain functions that tend to decline with age.
Recognizes phosphatidylserine (PS) in cell membranes.
Liposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol.
Detect Phosphatidylserine using this Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor 488 validated for use in FC.
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Flow Cytometry: 0.2 μg of this antibody detected Phosphatidylserine in fixed Jurkat cells (see page 2).
Apoptosis Assay: Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate or an Annexin V FITC conjugate.
Protein G Purified
Purified mouse monoclonal IgG in buffer containing PBS containing 1% BSA, 0.05% Tween, 0.05% sodium azide. Liquid at 4ºC.
Storage and Stability
Stable for 1 year at from date of receipt.
Staurosporine treated Jurkat cells.
Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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