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218759

Sigma-Aldrich

Caspase-8 Inhibitor II

The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
Empirical Formula (Hill Notation):
C30H43FN4O11
Molecular Weight:
654.68

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to yellow

solubility

DMSO: 10 mM

shipped in

ambient

storage temp.

−20°C

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218744218746SCP0094
Sigma-Aldrich

Sigma-Aldrich

218759

Caspase-8 Inhibitor II

Sigma-Aldrich

Sigma-Aldrich

218744

Caspase-2 Inhibitor I

Caspase-1 Inhibitor VI Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5.

Sigma-Aldrich

218746

Caspase-1 Inhibitor VI

Sigma-Aldrich

Sigma-Aldrich

SCP0094

Caspase Inhibitor

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

protect from light

color

white to yellow

color

-

color

white

color

-

solubility

DMSO: 10 mM

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

solubility

-

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

-

General description

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-8
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

Analysis Note

≥98% (HPLC)

Other Notes

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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María Segovia et al.
Journal of phycology, 45(5), 1116-1126 (2009-10-01)
When the chlorophyte alga Dunaliella tertiolecta Butcher is placed in darkness, a form of programmed cell death with many similarities to apoptosis is induced, including the induction of caspase-like proteases. Many uncertainties about the regulation and mediators that participate in
Zahara L Chaudhry et al.
Brain sciences, 12(4) (2022-04-22)
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in host, which may exacerbate symptoms and/or
W D Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 165(10), 5612-5620 (2000-11-09)
Past studies have shown that TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in a high proportion of cultured melanoma by caspase-dependent mechanisms. In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector
Zahara L Chaudhry et al.
Brain sciences, 10(11) (2020-11-05)
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence
Gurdeep Marwarha et al.
Biomedicines, 10(1) (2022-01-22)
Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia-reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress. However, to date, no consensus has emerged with regards to
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