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317240

Sigma-Aldrich

Metformin

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

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Synonym(s):
Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
Empirical Formula (Hill Notation):
C4H11N5 · xHCl
CAS Number:
Molecular Weight:
129.16 (free base basis)
MDL number:
NACRES:
NA.77

Quality Level

Assay

≥97% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

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This Item
PHR1084M06050001396309
Metformin An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

Sigma-Aldrich

317240

Metformin

Metformin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1084

Metformin hydrochloride

Metformin hydrochloride European Pharmacopoeia (EP) Reference Standard

M0605000

Metformin hydrochloride

Metformin hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1396309

Metformin hydrochloride

form

solid

form

-

form

-

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

EDQM

manufacturer/tradename

USP

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

storage condition

-

storage condition

-

color

white

color

-

color

-

color

-

solubility

water: 50 mg/mL

solubility

-

solubility

-

solubility

-

General description

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

Biochem/physiol Actions

Cell permeable: no
Primary Target
AMP-activated protein kinase (AMPK)
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Sigma-Aldrich

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