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616374

Sigma-Aldrich

TRAIL, Human, Recombinant, E. coli

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Synonym(s):
Apo2L, Human, Recombinant, E. coli, TNF-Related Apoptosis-Inducing Ligand, Human, Recombinant, E. coli

Assay

≥95% (SDS-PAGE)

Quality Level

100

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μg endotoxin (EU/μg TRAIL)

shipped in

wet ice

storage temp.

−70°C

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TRAIL Protein, Recombinant human

form

liquid

form

lyophilized

form

liquid

form

-

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

OK to freeze

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

-

impurities

<0.1 EU/μg endotoxin (EU/μg TRAIL)

impurities

≤1 EU/μg Endotoxin (EU/μg TRAIL)

impurities

-

impurities

<0.1 ng/μg Endotoxin (of TRAIL/Apo2L; 1EU/μg)

shipped in

wet ice

shipped in

ambient

shipped in

wet ice

shipped in

dry ice

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

-

General description

Recombinant, human TRAIL (amino acids 114-281) expressed in E. coli. Ligand for TRAIL receptors DR4 and DR5. Displays potent antitumor activity against selected targets and induces apoptosis in a number of transformed cell lines, but not in normal tissues.

Biochem/physiol Actions

Induces apoptosis in U937 cells at 1 μg/ml within 5 h.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 500 mM NaCl, 10 mM Na₂HPO₄, 2.7 mM KCl, 2 mM KH₂PO₄, 0.1 mM DTT, ≤10% glycerol.

Reconstitution

Following initial thaw, aliquot and freeze

(-70°C).

Other Notes

Lin, Y., et al. 2000. Mol. Cell. Biol.20, 6638.
Mitsaides, N., et al. 2000. Cancer Res.60, 4122.
Griffith, T.S., et al. 1999. J. Exp. Med.189, 1343.
Mariani, S.M., et al. 1997. J. Cell Biol.137, 221.
Pan, G., et al. 1997. Science276, 111.
Pan, G., et al. 1997. Science277, 815.
Sheridan, J.P., et al. 1997. Science277, 818.
Pitti, R.M., et al. 1996. J. Biol. Chem.271, 12687.
Wiley, S.R., et al. 1995. Immunity3, 673.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Oliver H Voss et al.
Cell death & disease, 12(4), 287-287 (2021-03-19)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selective killing of cancer cells underlines its anticancer potential. However, poor tolerability and resistance underscores the need to identify cancer-selective TRAIL-sensitizing agents. Apigenin, a dietary flavonoid, sensitizes lung cancer cell lines to TRAIL. It

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