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AB5380

Sigma-Aldrich

Anti-Nitric Oxide Synthase I Antibody

serum, Chemicon®

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Synonym(s):
NOS I, bNOS, nNOS
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, sheep, rat, human, monkey

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NOS1(4842)

Specificity

Recognizes Neuronal nitric oxide synthase (nNOS, NOS-I, bNOS). No cross reaction with iNOS and eNOS by immunohistochemistry.

Immunogen

Recombinant human neuronal nitric oxide synthase.

Application

Research Category
Neuroscience
Research Sub Category
Oxidative Stress
This Anti-Nitric Oxide Synthase I Antibody is validated for use in IH, WB for the detection of Nitric Oxide Synthase I.
Western blot: 1:1,000-1:3,000 (ECL).

Immunohistochemistry: 1:1,000-1:2,000 (ABC).

Optimal working dilutions must be determined by end user.

Target description

161 kDa

Linkage

Replaces: AB1552

Physical form

Rabbit Serum. Liquid containing 0.05% sodium azide.
Unpurified

Storage and Stability

Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sun Min Lee et al.
Journal of neurogastroenterology and motility, 23(4), 592-605 (2017-08-05)
Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide synthase (nNOS) with regard to age-related changes between the ascending colon
Hui Dong et al.
American journal of physiology. Cell physiology, 308(5), C405-C413 (2014-12-30)
Mechanosensitivity of enteric neurons has been reported in the small intestine and colon, but not in the esophagus. Our earlier in vivo studies show that mechanical stretch of the esophagus in the axial direction induces neurally mediated relaxation of the
Yong Hwan Kwon et al.
PloS one, 12(1), e0169113-e0169113 (2017-01-04)
The gastric accommodation reflex is an important mechanism in gastric physiology. However, the aging-associated structural and functional changes in gastric relaxation have not yet been established. Thus, we evaluated the molecular changes of interstitial cell of Cajal (ICC) and neuronal
Gaetano Scala et al.
Anatomical record (Hoboken, N.J. : 2007), 290(11), 1399-1412 (2007-10-12)
Choroid plexuses (CPs) play pivotal roles in many processes that establish, survey, and maintain the biochemical and cellular status of the central nervous system (CNS). Changes in the anatomy and physiology of CPs have been linked to several CNS diseases.
Guo-Du Wang et al.
American journal of physiology. Gastrointestinal and liver physiology, 291(5), G928-G937 (2006-10-13)
Platelet-activating factor (PAF) is a proinflammatory mediator that may influence neuronal activity in the enteric nervous system (ENS). Electrophysiology, immunofluorescence, Western blot analysis, and RT-PCR were used to study the action of PAF and the expression of PAF receptor (PAFR)

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