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CBL1366

Sigma-Aldrich

Anti-CD140a Antibody, clone APA5

clone APA5, Chemicon®, from rat

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Synonym(s):
PDGF Receptor alpha
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

APA5, monoclonal

species reactivity

mouse

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PDGFRA(5156)

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SAB4502142SAB4700455SAB4502139
Sigma-Aldrich

CBL1366

Anti-CD140a Antibody, clone APA5

biological source

rat

biological source

rabbit

biological source

mouse

biological source

rabbit

clone

APA5, monoclonal

clone

polyclonal

clone

16A1, monoclonal

clone

polyclonal

Gene Information

human ... PDGFRA(5156)

Gene Information

human ... PDGFRA(5156)

Gene Information

human ... PDGFRA(5156)

Gene Information

human ... PGFRA(5156)

species reactivity

mouse

species reactivity

human, mouse, rat

species reactivity

human

species reactivity

rat, human, mouse

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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Specificity

Specifically recognizes mouse CD140a, the alpha chain of PDGF receptor. A receptor tyrosine kinase, PDGFRa forms dimers on the surface upon ligand binding and phosphorylates substrates. CD140a is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues.

Application

Detect CD140a using this Anti-CD140a Antibody, clone APA5 validated for use in ELISA, FC, WB, IH.
Flow Cytometry: ≤ 1 μg per 10E6 cells

ELISA

Immunohistochemistry: 10μg/mL

Blocking of Ligand Binding

Western Blotting

Optimal working dilutions must be determined by the end user.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Physical form

Format: Purified
Purified immunoglobulin in PBS, 150 mM NaCl, pH 7.2, containing 0.09% sodium azide.

Storage and Stability

Maintain at 2-8°C for up to 12 months from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificates of Analysis (COA)

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Maria Anesti et al.
Cells, 11(11) (2022-06-11)
Two main stem cell pools exist in the postnatal mammalian brain that, although they share some "stemness" properties, also exhibit significant differences. Multipotent neural stem cells survive within specialized microenvironments, called niches, and they are vulnerable to ageing. Oligodendroglial lineage-restricted
Bilal El Waly et al.
iScience, 25(10), 105102-105102 (2022-10-04)
After demyelinating insult, the neuronal progenitors of the adult mouse sub-ventricular zone (SVZ) called neuroblasts convert into oligodendrocytes that participate to the remyelination process. We use this rare example of spontaneous fate conversion to identify the molecular mechanisms governing these
Magali Macchi et al.
eLife, 9 (2020-06-10)
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan
Haley E Titus et al.
Glia, 70(10), 1950-1970 (2022-07-10)
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and promote repair/regeneration of myelin as well as maintenance of axonal
Francesco Girolamo et al.
Neurobiology of disease, 43(3), 678-689 (2011-06-18)
Experimentally induced autoimmune encephalomyelitis (EAE) in mice provides an animal model that shares many features with human demyelinating diseases such as multiple sclerosis (MS). To what extent the cerebral cortex is affected by the process of demyelination and how the

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