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PHR1121

Supelco

2-Phenoxyethanol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Ethylene glycol monophenyl ether, Phenylglycol
Linear Formula:
C6H5OCH2CH2OH
CAS Number:
Molecular Weight:
138.16
Beilstein:
1364011
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. P0950000
traceable to USP 1526200

API family

phenoxyethanol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

244-246 °C

mp

11-13 °C

density

1.107 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OCCOc1ccccc1

InChI

1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2

InChI key

QCDWFXQBSFUVSP-UHFFFAOYSA-N

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General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions.

Application

The pharmaceutical secondary standard can also be used as follows:
  • To determine phenoxyethanol and its major metabolite, phenoxyacetic acid by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma, urine, and 7 different tissue samples
  • Development of a reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method to quantify 2-phenoxyethanol from commercially available human vaccines
  • Screening of cosmetic products (CPs) for 17 widely used preservatives by high-performance liquid chromatography-photodiode-array-electrospray ionization-mass spectrometry (HPLC-PDA-ESI/MS)
  • Thin layer chromatography (TLC)-densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in cream samples
  • Analysis of eight volatile and semi-volatile ingredients in a topical formulation by gas chromatography (GC) coupled with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2814 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 1

Flash Point(F)

258.8 °F

Flash Point(C)

126 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in creams
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