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A8301

Sigma-Aldrich

Albumin, glycated human

lyophilized powder

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CAS Number:
70024-90-7
MDL number:
MFCD00130433
NACRES:
NA.25

biological source

human

Quality Level

200

Assay

90-100% protein basis (biuret)

form

lyophilized powder

extent of labeling

1-5 mol hexose (as fructosamine) per mol albumin

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P02768

storage temp.

−20°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

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This Item
A3782A1887A9511
Sigma-Aldrich

Sigma-Aldrich

A8301

Albumin, glycated human

Albumin from human serum lyophilized powder, Fatty acid free, Globulin free, ≥99% (agarose gel electrophoresis)

Sigma-Aldrich

A3782

Albumin from human serum

Albumin from human serum lyophilized powder, essentially fatty acid free

Sigma-Aldrich

A1887

Albumin from human serum

Albumin from human serum lyophilized powder, ≥97% (agarose gel electrophoresis)

Sigma-Aldrich

A9511

Albumin from human serum

assay

90-100% protein basis (biuret)

assay

≥99% (agarose gel electrophoresis)

assay

≥96% (agarose gel electrophoresis)

assay

≥97% (agarose gel electrophoresis)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

General description

Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains.

Application

Albumin, glycated human has been used:
  • as a component of serum-free medium for retinal microglia activation
  • to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production
  • as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression


Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.

Biochem/physiol Actions

Albumin is crucial for physiological processes and is the major transporter for lipids, metal ions and amino acids. It has antioxidant functionality and binds to drugs as well. Mutation in the albumin gene is implicated in an autosomal recessive disorder called Analbuminemia, which is characterized by low levels of albumin. The major glycation site is lysine 525 in albumin. Glycated albumin is a marker of glycemia in diabetes mellitus patients and is useful in assessment of HbA1c based glycemic control.

Physical form

Lyophilized powder containing citrate buffer salts

Preparation Note

Glycated in vitro

Other Notes

View more information on human serum albumin.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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A novel mutation in the albumin gene (c. 1A> C) resulting in analbuminemia
Caridi G, et al.
European Journal of Clinical Investigation, 43(1), 72-78 (2013)
Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
Inaba M, et al.
Journal of the American Society of Nephrology, 18(3), 896-903 (2007)
Glycated albumin: a potential biomarker in diabetes
Freitas P, et al.
Archives of endocrinology and metabolism, 61(3), 296-304 (2017)
CCL18 synergises with high concentrations of glucose in stimulating fibronectin production in human renal tubuloepithelial cells
Montero RM, et al.
BMC Nephrology, 17(1), 139-139 (2016)
Role of FAM18B in diabetic retinopathy
Wang AL, et al.
Molecular Vision, 20(1), 1146-1146 (2014)
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