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C2969

Sigma-Aldrich

Monoclonal Anti-I-CAM-1 (CD54) antibody produced in mouse

clone 8.4A6, purified immunoglobulin

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Synonym(s):
Monoclonal Anti-CD54, Anti-I-CAM-1
MDL number:

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

8.4A6, monoclonal

mol wt

antigen 85-110 kDa

species reactivity

human, monkey

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ICAM1(3383)

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This Item
SAB4700328SAB4700326SAB4700329
conjugate

unconjugated

conjugate

phycoerythrin (R-PE) conjugate

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

8.4A6, monoclonal

clone

MEM-111, monoclonal

clone

MEM-112, monoclonal

clone

1H4, monoclonal

mol wt

antigen 85-110 kDa

mol wt

-

mol wt

-

mol wt

-

species reactivity

human, monkey

species reactivity

human, rat, bovine

species reactivity

human

species reactivity

human

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Specificity

The antibody recognizes the human CD54 (I-CAM-1) surface antigen by flow cytometry, ELISA, immunocytochemistry, and immunohistochemistry. It inhibits human leukocyte adhesion to activated endothelial cells and stimulates homotypic aggregation of SKW3 cells. The epitope recognized by the antibody is localized in domain D2 of the CD54 molecule.
5th Workshop: code no. S 100

Immunogen

TNF-α activated human endothelial cells.

Target description

CD54 (I-CAM-1) is a glycoprotein involved in mediation of intercellular adhesion. CD54 is expressed by activated endothelial cells and is also detected on cells of many other lineages and in plasma.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4.

Preparation Note

Product filtered through a 0.2 μm filter

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Lanlan Tang et al.
Oncotarget, 8(16), 27314-27327 (2017-04-14)
Differentiation therapy based on all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) for the treatment of acute promyelocytic leukemia (APL) is complicated by the development of differentiation syndrome (DS), which can be fatal. We examined the role of HMGB1 (high-mobility group

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