N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.
Anti-N-Cadherin antibody is suitable for the following procedures:
- electron microscopy
- flow cytometry
- immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
- western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts
200 μL in glass bottle
CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.
0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
Clone GC-4 is also known as GB-9.
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