Merck
All Photos(5)

G4386

Sigma-Aldrich

γ-Globulins from human blood

≥99% (electrophoresis)

Synonym(s):
Human γ-Globulin
CAS Number:
MDL number:
NACRES:
NA.61

biological source

human blood

Quality Level

assay

≥99% (electrophoresis)

form

powder

technique(s)

protein quantification: suitable

impurities

HIV, HCV and HBsAg, source material tested negative
≤4% NaCl

solubility

0.9% NaCl: soluble 50 mg/mL

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... IGLL1(3543)

Looking for similar products? Visit Product Comparison Guide

General description

γ-Globulins are immunoglobulins and occur in five classes, namely: IgG, IgM, IgA, IgD, and IgE. These are glycoproteins that are antibodies produced by plasma cells. The immunoglobulins are heterogeneous molecules made up of four polypeptide chains (two light chains and two heavy chains) linked together by disulfide bonds. The antigen-binding site is present at the nitrogen terminal. 20% of the protein in plasma are immunoglobulins.

Application

γ-Globulins from human blood have been used for the blocking step in cytometric bead array It has also been used as a standard for γ-globulin measurement in cerebrospinal fluid (CSF).
γ-globulins were used to study a micro-method for measuring total protein in cerebrospinal fluid by using benzethonium chloride in microtiter plate wells. It was used in the measurement of protein in tannin-protein precipitates using ninhydrin. It was also used to study the blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans.

Packaging

250 mg in poly bottle
1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

Immunoglobulins are key regulators of the immune system and are produced in response to antigens. They protect our bodies against bacteria, viruses, and fungi. Immunoglobulins are involved in the activation of the complement system, opsonization of microbes for phagocytosis, neutralization of toxins and viruses, and inhibition of the attachment of microbes to mucosal surfaces. Immunodeficiency can lead to recurrent infectious diseases.

Preparation Note

Prepared from Cohn Fraction II, III

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Product Information Sheet

SDS

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service