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I4276

Sigma-Aldrich

Interferon-αA human

≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli

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Synonym(s):
IFN-αA, Interferon-α2A
CAS Number:
105388-21-4
MDL number:
MFCD01635115

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

≥95%

form

buffered aqueous solution

mol wt

19 kDa

packaging

pkg of 20 μg

concentration

≥0.2 mg/mL

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

UniProt accession no.

P01563

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IFNA2(3440)

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SRP3059I3265H6166
Interferon-αA human ≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli

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I4276

Interferon-αA human

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SRP3059

Interferon-λ human

Interferon-γ human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture

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I3265

Interferon-γ human

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H6166

Interferon α 2B human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

assay

≥95%

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

form

lyophilized

form

lyophilized powder

form

lyophilized powder

mol wt

19 kDa

mol wt

19.8 kDa

mol wt

~17 kDa

mol wt

dimer 16 kDa (glycosylated)

packaging

pkg of 20 μg

packaging

pkg of 20 μg

packaging

pkg of 0.1 mg

packaging

poly bottle of 10 μg (in poly bottle)

Application

Interferon-αA human has been used to:
  • study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
  • study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
  • compare the effect of Monascus pigment derivatives on hepatitis C virus replication

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Physical form

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ji-Min Sun et al.
The Journal of antimicrobial chemotherapy, 67(1), 49-58 (2011-11-15)
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of Monascus pigment derivatives, which were derived from a microbial secondary metabolite synthesized
S-J Kim et al.
Journal of viral hepatitis, 16(10), 697-704 (2009-02-27)
Hepatitis C virus (HCV) infection is a serious threat to human health worldwide. In spite of the continued search for specific and effective anti-HCV therapies, the rapid emergence of drug-resistance variants has been hampering the development of anti-HCV drugs designed
Jelke J Fros et al.
Journal of virology, 84(20), 10877-10887 (2010-08-06)
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon
Shuai Shao et al.
JCI insight, 6(20) (2021-09-08)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the molecular signatures these skin disorders share are unknown. Using
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed
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