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I8657

Sigma-Aldrich

Interferon α from rat

≥95%, recombinant, expressed in bacteria, lyophilized powder, suitable for cell culture

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Synonym(s):
IFN-α
MDL number:
NACRES:
NA.32

biological source

rat

Quality Level

recombinant

expressed in bacteria

Assay

≥95%

form

lyophilized powder

mol wt

~19 kDa

packaging

pkg of 1 vial

concentration

300,000-800,000,000 units/mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

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I8657

Interferon α from rat

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I4401

Interferon-αA/D human

Interferon-γ from rat ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I3275

Interferon-γ from rat

recombinant

expressed in bacteria

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥95%

assay

≥95%

assay

≥95%

assay

≥97% (SDS-PAGE)

form

lyophilized powder

form

buffered aqueous solution

form

buffered aqueous solution

form

lyophilized powder

mol wt

~19 kDa

mol wt

20 kDa

mol wt

19 kDa

mol wt

15.5 kDa

packaging

pkg of 1 vial

packaging

-

packaging

pkg of 100K units

packaging

pkg of 0.1 mg

General description

Interferon α is a cytokine, that belongs to type I interferon (IFNs) family. It possesses 14 genes, including 2 pseudo-genes or allelic forms that encodes for 13 proteins. It is mainly induced in response to viral infection. It is a non-leukemogenic peptide.

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
Interferon α play a key role in the inhibition of in vitro proliferation of hematopoietic progenitors. It mediates the regulation of gene expression that is responsible for development and functionality of innate and adaptive immunity. It has been used as myelosuppressive agent for myeloproliferative neoplasms (MPNs).

Physical form

Lyophilized from a solution containing citric acid buffered saline (CBS pH 5.0) and 125 mM trehalose

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV) in the presence of 2mM glutathione. The cytopathic effect of 50% is produced with ~1 unit/mL interferon. Since there is no international rat interferon α standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Jin Zhao et al.
PloS one, 8(5), e64301-e64301 (2013-06-07)
The cytokine interleukin-28B (IL-28B) has potential antiviral properties and regulatory roles in adaptive cellular immunity. A genome-wide association study identified a single nucleotide polymorphism near the IL-28B gene that strongly predicts response to hepatitis C treatment with interferon and ribavirin.
Interferon- ? therapy in bcr-abl-negative myeloproliferative neoplasms
Kiladjian JJ, et al.
Leukemia, 22(11), 1990-1990 (2008)
Type I interferons (?/?) in immunity and autoimmunity
Theofilopoulos AN, et al.
Fish & Shellfish Immunology, 23(11), 307-335 (2005)
Agnieszka Rynda et al.
PloS one, 5(1), e8720-e8720 (2010-01-22)
Conventional methods to induce tolerance in humans have met with limited success. Hence, efforts to redirect tolerogen uptake using reovirus adhesin, protein sigma 1 (psigma1), may circumvent these shortcomings based upon the recent finding that when reovirus psigma1 is engineered
The interferon system of teleost fish
Robertsen B
Fish & Shellfish Immunology, 20(2), 172-191 (2006)

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