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SAB3500124

Sigma-Aldrich

Monoclonal Anti-CD4L antibody produced in mouse

clone 9H5A8, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-CD4 antigen, Anti-CD4 receptor
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9H5A8, monoclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CD4(920)

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This Item
SAB4700059SAB4503583C1805
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified from hybridoma cell culture

clone

9H5A8, monoclonal

clone

MEM-241, monoclonal

clone

polyclonal

clone

Q4120, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

mouse, human, rat

species reactivity

human

species reactivity

human, mouse

species reactivity

human

General description

Cluster of differentiation (CD4) encodes a T-cell surface glycoprotein CD4. In human chromosome, the gene CD4 is localized on 12p13.31.

Immunogen

raised against a 193 amino acid recombinant protein from near the amino terminus of human CD4.

Biochem/physiol Actions

Cluster of differentiation (CD4) mutation in single nucleotide causes OKT4 (Leu-3 T4) epitope deficiency. CD4 plays a major role in collateral artery formation by recruiting macrophages at the active site and through triggering the synthesis of arteriogenic cytokines.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Gene-expression profiling of titanium-cell interaction
Kim CS, et al.
The Journal of Korean Academy of Prosthodontics, 43(3), 393-408 (2005)
OKT4 epitope deficiency in patients infected with the human immunodeficiency virus: a cause of underestimation of the CD4 lymphocyte count
Khuong MA, et al.
Clinical Infectious Diseases, 19(5), 961-963 (1994)
Impaired Arteriogenic Response to Acute Hindlimb Ischemia in CD4-Knockout Mice
Stabile E, et al.
Cytokines, 108(5), 205-210 (2003)

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