SAB4502850

Anti-SREBP-1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1, sterol regulatory element-binding transcription factor 1
• MDL number: MFCD02264110
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 121 kDa
• species reactivity: human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P36956
• UniProt accession no.: P36956
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... SREBF1(6720)

Description

General description

Anti-SREBP-1 Antibody detects endogenous levels of total SREBP-1 protein.

Sterol regulatory element binding protein-1 (SREBP1) is located on human chromosome 17p11.2. It belongs to the bHLH-Zip transcription factor family. SREBP-1 is a membrane-bound transcription factor liberated by sterol-regulated proteolysis.It is a 125 kD precursor that is bound to the nuclear envelope and endoplasmic reticulum.

Immunogen

The antiserum was produced against synthesized peptide derived from human SREBP-1.

Immunogen Range: 405-454

Biochem/physiol Actions

Sterol regulatory element binding protein-1 (SREBP1) participates in the transcriptional regulation of cellular lipid homeostasis. It controls the hepatic gene expression of lipogenic enzymes and triglyceride deposition in the liver.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable