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SAB5500064

Sigma-Aldrich

Anti-CD4 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP35, affinity isolated antibody

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Synonym(s):
Anti-CD4mut, Anti-IMD79, Anti-OKT4D
NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP35, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

pig

technique(s)

flow cytometry: 1:100
immunohistochemistry: 1:50

isotype

IgG

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD4(920)

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This Item
SAB5600099SAB5500040SAB5500057
recombinant

expressed in proprietary host

recombinant

expressed in HEK 293 cells

recombinant

expressed in proprietary host

recombinant

expressed in proprietary host

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

SP35, monoclonal

clone

RM291, monoclonal, recombinant monoclonal

clone

SP192, monoclonal

clone

SP162, monoclonal

species reactivity

human (tested)

species reactivity

human

species reactivity

human (tested)

species reactivity

human (tested)

General description

CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV and is expressed in T cell lymphomas. Non-specific nuclear staining is sometimes seen in follicles with this antibody; however in most cases it does not interfere with the interpretation of the CD4 membrane staining.

Immunogen

Synthetic peptide corresponding to internal region of human CD4.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Daniela Alejandra Rios et al.
Scientific reports, 7(1), 13283-13283 (2017-10-19)
The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver
Akihiro Kitadate et al.
Haematologica, 103(1), 126-135 (2017-10-14)
Histone deacetylase inhibitors are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia. CCR4 is an important therapeutic target molecule because mogamulizumab, an anti-CCR4 antibody, has shown promising efficacy against various T-cell
Julie Jacobs et al.
Oncoimmunology, 7(7), e1440167-e1440167 (2018-06-15)
Cancer-associated fibroblasts (CAFs) are involved in the proliferative and invasive behavior of colorectal cancer (CRC). Nonetheless, CAFs represent a heterogeneous population with both cancer-promoting and cancer-restraining actions, lacking specific markers to target them. Expression of the immune checkpoint molecule CD70
Thomas Albrecht et al.
Cancers, 13(7) (2021-05-01)
Inhibition of the programmed cell death protein-1/ligand-1 (PD-1/PD-L1) axis has opened a new era in the treatment of solid cancers. However, there is no data on the expression and relevance of PD-L1 in Western gallbladder cancer (GBC). We assessed PD-L1
Kazuhiko Hashimoto et al.
European journal of histochemistry : EJH, 65(3) (2021-07-06)
Inhibitors of the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint system are used for treating various malignancies. However, evidence on their use in soft tissue sarcomas (STS) is limited. This study aimed to retrospectively investigate the relationship between the expression

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