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SML1224

Sigma-Aldrich

Torin2

≥98% (HPLC)

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Synonym(s):
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Empirical Formula (Hill Notation):
C24H15F3N4O
CAS Number:
Molecular Weight:
432.40
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChI key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

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This Item
475992475991SML1728
Sigma-Aldrich

Sigma-Aldrich

SML1224

Torin2

STK16-IN-1 ≥98% (HPLC)

Sigma-Aldrich

SML1728

STK16-IN-1

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

yellow

color

yellow-white

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL

solubility

DMSO: 2 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Torin2 has been used:
  • to examine its effect on LC3B-II levels in BORCS5- KO cells
  • to determine its potent activity (IC50 less than 1 μM) against A2780-cis ovarian cancer cells
  • in western blot analysis

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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