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IFN-alpha 2b human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

IFNA, INFA2, Interferon α 2b

biological source



expressed in E. coli


≥98% (HPLC)
≥98% (SDS-PAGE)




>2.0x10^7 units/mg

mol wt

~19.3 kDa


pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles


endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... IFNA2b(3440)

General description

The gene IFN-α2b (interferon α 2b) is mapped to human chromosome 9. The encoded protein is a type 1 interferon and a glycoprotein. It belongs to the class of cytokines. Human IFN-α2b is a 19.3kDa protein containing 165 amino acid residues. Structurally, IFN-α2b is O-glycosylated at the threonine residue at position 106.


IFN-α2b human has been used:
  • as an immunotherapeutic agent to test its antiproliferative and proapoptotic effects in RCC cell lines
  • to stimulate peripheral blood mononuclear cell (PBMC) prior to RNA isolation
  • to stimulate H4 cells before immunoprecipitation
  • to study role of USP18 (ubiquitin specific peptidase 18)-mediation deISGylation in controlling cellular autophagy upon treatment with type I interferons

Biochem/physiol Actions

IFN-α2b (interferon α 2b) is a lymphoid factor that possesses potent anti-viral activity. It mainly interacts with cell surface-specific receptors. This interaction is responsible for anti-pathogenic response in cells. IFN-α2b also exhibits anti-tumor activities. Humans with brain tumor were shown to have mutations in this gene. IFN-α2b induces the secretion of cytokine IFN-γ in T cells. The hydrogels embedded with IFN-α2b exploits this functionality in gastric cancer cells. Recombinant IFN-α types are effective against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in in vitro studies.

Physical form

Lyophilized from 5 mM sodium phosphate, pH 7.4.


Reconstitute in water to a concentration of 1 mg/mL. This solution can then be diluted into other aqueous buffers. Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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