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SRP4634

Sigma-Aldrich

VEGF-C from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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Synonym(s):
VEGFC, Vascular Endothelial Growth Factor-C
MDL number:
MFCD03458368
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

lyophilized

potency

>200 ng/mL ED50

mol wt

~18.0 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P97953

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Vegfc(22341)

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VEGF-C from mouse recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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VEGF-C from mouse

VEGF165 from mouse recombinant, expressed in E. coli

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SRP4364

VEGF165 from mouse

VEGF164 from mouse recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

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SRP6430

VEGF164 from mouse

VEGF-C human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP4633

VEGF-C human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

assay

≥98%

assay

≥95% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

~18.0 kDa

mol wt

~39.0 kDa

mol wt

calculated mol wt 19.3 kDa (no tag), observed mol wt 23-25 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminal.)

mol wt

15-16 kDa

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

General description

VEGF-C (vascular endothelial growth factor-C) is a member of the VEGF family of structurally related proteins. The gene encoding this protein is localized on mouse chromosome 8. The product here (VEGF-C from mouse) is a 129 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. Mouse VEGF-C exhibits about 85% homology with human and 97% homology with rat VEGF-C.

Biochem/physiol Actions

VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions via the VEGF receptor-3 (VEGFR-3). Studies have shown that lymphatic endothelial cells do not form sprouting capillaries without VEGF-C. It has also been observed that this protein stimulates tumor lymphangiogenesis in xenotransplanted and transgenic mouse models of cancer.

Physical form

Lyophilized from acetic solution with 50 μg BSA per 1 μg VEGF-C.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites.
Hirakawa S
Blood, 109(3), 1010-1017 (2007)
Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.
Lliersch R
International Journal of Oncology, 41(6), 2073-2078 (2012)
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Karkkainen MJ
Nature Immunology, 5(1), 74-80 (2004)
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors.
Tuomela J
BMC Cancer, 9, 362-362 (2009)
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
Holmes DI and Zachary I
Genome Biology, 6(2), 209-209 (2005)
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